Computational methods for alternative splicing prediction.

Identification of alternative 50/30 splice sites based on the mechanism of splice site competition

Alternative splicing plays an important role in regulating gene expression. Currently, most efficient methods use expressed sequence tags or microarray analysis for large-scale detection of alternative splicing. However, it is difficult to detect all alternative splice events with them because of their inherent limitations. Previous computational methods for alternative splicing prediction coul...

Identification of alternative 5′/3′ splice sites based on the mechanism of splice site competition

Alternative splicing plays an important role in regulating gene expression. Currently, most efficient methods use expressed sequence tags or microarray analysis for large-scale detection of alternative splicing. However, it is difficult to detect all alternative splice events with them because of their inherent limitations. Previous computational methods for alternative splicing prediction coul...

Bioinformatics Analyses of Alternative Splicing, Est-based and Machine Learning-based Prediction

Alternative splicing is a mechanism for generating different gene transcripts (called isoforms) from the same genomic sequence. Finding alternative splicing events experimentally is both expensive and time consuming. Computational methods in general, and EST analysis and machine learning algorithms in particular, can be used to complement experimental methods in the process of identifying alter...

Human Full-Length Pre-mRNA Sequence Dataset for Computational Gene Prediction and Alternative Splicing Analysis

Role of Aberrant Alternative Splicing in Cancer

Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...